|Storage:||Inert Atmosphere,Room Temperature||Boiling Point:||534.7±50.0 °C(Predicted)|
GMP NSI 189 Nootropic,
Pharmaceutical NSI 189 Nootropic,
1270138-40-3 NSI 189 Nootropic
GMP Certificated Pharmaceutical Nsi-189 API Powder CAS 1270138-40-3 with Best Price
NSI-189 is a nootropic and neurogenic research chemical derived from nicotinamide and pyrazine.IC50 value:Target: in vitro: NSI-189 has been shown to stimulate neurogenesis of human hippocampus-derived neural stem cells in vitro and in vivo. The hippocampus is responsible for the consolidation of information from short-term memory to long-term memory, along with spatial navigation  .in vivo: NSI-189 has been shown to increase the hippocampal volume of healthy adult mice by 20%.
Tests have shown that NSI-189 significantly improved behavioral responses that are associated with depression . In humans it may counter hippocampal atrophy which is seen in disorders such as MDD, reversing their symptoms. A phase 1B randomized, double-blind, placebo-controlled, multiple-dose escalation study conducted over a 28 day period showed behavioral efficacy in 24 patients who were orally administered NSI-189 . The efficacy measurements showed a clinically meaningful reduction in cognitive and depressive symptoms across all measures, and appeared to persist over time during follow up for the efficacy assessments which included the Clinical Global Impression - Improvement (CGI-I), Montgomery-Aserb Depression Rating Scale (MADRS), Cognitive and Physical Functioning Questionnaire (CPFQ, and the Symptoms of Depression Questionnaire (SDQ) .
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