Antifungal Antibiotic Nystatin Powder,
Pharmaceutical Material Nystatin Powder,
Nystatin CAS 1400-61-9
Nystatin is a polyene antifungal drug to which many molds and yeast infections are sensitive, including Candida.Cutaneous, vaginal, mucosal and esophageal Candida infections usually respond well to treatment with nystatin.Like amphotericin B and natamycin, nystatin binds to ergosterol, a major component of the fungal cell membrane. When present in sufficient concentrations, it forms pores in the membrane that lead to K+ leakage and death of the fungus.
Nystatin is a kind of polyene antibiotic. In 1950, it was found that soil microorganism Streptomyces noursei could secrete an anti fungal substance, thus the first anti fungal antibiotic was found. Nystatin has conjugated polyene macrolide structure, which can inhibit the activities of fungi and dermatophytes, but has no inhibitory effect on bacteria.
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