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Product Details:
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| Product Name: | 5-Azacytosine | Other Name: | 5-triazin-2(1h)-one,4-amino-3 |
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| CAS No: | 931-86-2 | Purity: | 99% Min |
| Shelf Life: | 2 Years | Application: | Medication |
| Sample: | Available | Storage: | Cool And Dry Place |
| Appearance: | White Powder |
Product Introduction
Name: 5-Azacytosine
English synonyms: 5-triazin-2(1h)-one,4-amino-3
CAS Number: 931-86-2
Molecular formula: C3H4N4O
Molecular weight: 112.09
EINECS Number: 213-242-9
Product Description
Melting point: >300°C(lit.)
Boiling point: 209.98°C(rough estimate)
Density: 1.86 refractive index 1.8010 (estimate)
Storage conditions: Keep in dark place, Inert atmosphere, 2-8°C
Acidity coefficient (pKa): 7.61±0.10(Predicted)
Product Function
5-Azacytosine, also known as 4-amino-1,3,5-triazin-2-one, is the basic raw material for the synthesis of 5-azacytidine drugs. As a synthetic pyrimidine base, 5-azacytidine can be combined with ribose to form 5-azacytidine. It is a cytosine nucleoside drug that can penetrate into tumors as a pseudo-metabolite. Among the nucleic acids, it interferes with the physiological functions of tumor cells and produces anti-tumor effects.
The currently developed therapeutic drug with 5-azacytidine as raw material is 5-azacytidine, and the trade name is Vidaza. There is also 5-aza-2'-deoxycytidine, trade name Decitabine. The clinical efficacy of these drugs for myelodysplastic syndrome, myeloid leukemia, sickle cell anemia, and some solid tumors has been confirmed.
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