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Medicine Grade Valganciclovir Hydrochloride CAS 175865-59-5

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China Wuhan Senwayer Century Chemical Co., Ltd. certification
China Wuhan Senwayer Century Chemical Co., Ltd. certification
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Medicine Grade Valganciclovir Hydrochloride CAS 175865-59-5

Medicine Grade Valganciclovir Hydrochloride CAS 175865-59-5
Medicine Grade Valganciclovir Hydrochloride CAS 175865-59-5 Medicine Grade Valganciclovir Hydrochloride CAS 175865-59-5 Medicine Grade Valganciclovir Hydrochloride CAS 175865-59-5 Medicine Grade Valganciclovir Hydrochloride CAS 175865-59-5 Medicine Grade Valganciclovir Hydrochloride CAS 175865-59-5

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Product Details:
Place of Origin: China
Brand Name: Senwayer
Model Number: Valganciclovir Hydrochloride
Payment & Shipping Terms:
Minimum Order Quantity: 100g
Price: To be negotiated
Packaging Details: 1KG per foil bag, 25KG per drum.
Delivery Time: 5 working days
Payment Terms: T/T , bank transfer , Bitcoin , USDT
Supply Ability: 200KG per month

Medicine Grade Valganciclovir Hydrochloride CAS 175865-59-5

Description
Name: Valganciclovir Hydrochloride CAS: 175865-59-5
High Light:

Medicine Grade Valganciclovir Hydrochloride

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Valganciclovir Hydrochloride CAS 175865-59-5

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Medicine Raw Material CAS 175865-59-5

Hot Sale Supply Valganciclovir Hydrochloride Powder CAS 175865-59-5 with Safe Delivery

 

 

  • Product description
  • Product name
    Valganciclovir hydrochloride
    CAS No.
    175865-59-5
    Molecular Formula
    C14H23ClN6O5
    Molecular weight
    390.82
    Grade Standard Medicine Grade
    COA Avaliable
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  • Product introduction
  • Valganciclovir hydrochloride, a prodrug of the antiviral ganciclovir, was launched in the US for the oral treatment of cytemegalovirus (CMV) retinitis, a sight-threatening complication in patients with AIDS.  Valganciclovir is well absorbed and rapidly hydrolyzed to ganciclovir by intracellular esterases in the intestinal mucosal cells and by hepatic esterases. Unlike ganciclovir, valganciclovir was demonstrated to be actively transported by the intestinal peptide transporter PEPT1 in Caco-2 cells. As a consequence, its absolute bioavailability in human was 10-fold higher compared to ganciclovir (6%).

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  • In clinical trials, it was shown that a twice-daily 900 mg dose of valganciclovir resulted in similar systemic ganciclovir exposure to 5 mg/kg twice-daily intravenous injection of ganciclovir. Valganciclovir concentrations could not be quantified in most patients within three to four hours. In a randomized non-blind phase III clinical trial, oral valganciclovir (900 mg twice daily for three weeks then 900 mg once daily for one week) was as effective as intravenous ganciclovir (5 mg/kg twice daily for three weeks then 5 mg/kg once daily). Oral treatment with valganciclovir avoided catheter-related infection that sometimes occurred with intravenous ganciclovir.

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  • Product Application
Valganciclovir hydrochloride is used for preventing and treating CMV infection secondary to organ transplant recipients. This drug is a prodrug of ganciclovir, and it is an active valine ester of ganciclovir. After oral administration, it can be rapidly hydrolyzed into ganciclovir by phosphatase in intestinal and liver cells.
 
Its antiviral spectrum and action mechanism are similar to ganciclovir, but its bioavailability is significantly higher than that of ganciclovir. Its oral absorption bioavailability is 62.4%, which is 10 times that of ganciclovir, while its toxicity is greatly reduced.
 

 

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Contact Details
Wuhan Senwayer Century Chemical Co., Ltd.

Contact Person: Mrs. Angie Zhang

Tel: +8613627115097

Fax: 86-27-5970-7018

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