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CAS 19774-82-4 Powdered Amiodarone Hydrochloride Medicine Grade

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CAS 19774-82-4 Powdered Amiodarone Hydrochloride Medicine Grade

CAS 19774-82-4 Powdered Amiodarone Hydrochloride Medicine Grade
CAS 19774-82-4 Powdered Amiodarone Hydrochloride Medicine Grade

Large Image :  CAS 19774-82-4 Powdered Amiodarone Hydrochloride Medicine Grade

Product Details:
Place of Origin: china
Brand Name: senwayer
Certification: GMP&ISO
Model Number: Amiodarone Hydrochloride
Payment & Shipping Terms:
Minimum Order Quantity: 1kg
Price: To be negotiated
Packaging Details: foil bag, drum, vials
Delivery Time: 4-5days
Payment Terms: T/T, Western Union, MoneyGram
Supply Ability: 100KG per month

CAS 19774-82-4 Powdered Amiodarone Hydrochloride Medicine Grade

Description
Name: Amiodarone Hydrochloride CAS: 19774-82-4
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Powdered Amiodarone Hydrochloride

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Medicine Grade Amiodarone Hydrochloride

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CAS 19774-82-4 Medicine Powder

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  • Product description
  • Product name Amiodarone Hydrochloride
    CAS No.
    19774-82-4
    Other Names

    (2-Butylbenzofuran-3-yl)(4-(2-(diethylamino)ethoxy)-3,5-diiodophenyl)methanonehydrochloride

    Molecular Formula
    C25H29I2NO3.ClH
    Molecular weight
    681.77
    Grade Standard Medicine Grade
    COA Avaliable
  • Product introduction
  •  
  • Amiodarone is an antiarrhythmic drug for inhibition of ATP-sensitive potassium channel with IC50 of 19.1 μM. IC50 Value: 1.5 uM ( inhibit TBARS, LOOH and FPL formation)[1]in vitro: It was found that 10 uM amiodarone induces accumulation of ethidium bromide (5 ug/ml) in Saccharomyces cerevisiae cells. At the same time, in yeast cells with inactivated MDR genes, accumulation of ethidium bromide was 6-fold higher even without amiodarone. Addition of non-lethal concentrations of amiodarone to MDR-deficient cells caused an increase of intracellular ethidium bromide to the level, which was even lower than the level in amiodarone-treated wild-type cells [2]. Cells treated with amiodarone were seen to have detached from the dish, with cell rounding, cytoplasmic blebbing and irregularity in shape. An increase in the sub-G1 phase fraction, from 15.43 to 21.34% and 79.83% and a reduction in the G1 phase fraction, from 48.83 to 41.63% and 11.52%, were observed in cells treated with amiodarone at concentrations of 0.1 and 1 mM, respectively [3].in vivo: Chronic treatment with oral amiodarone for 4 weeks reduced i.p. when myocytes were dialyzed with patch-pipettes containing either 10 mM Na+ or 80 mM Na+. In myocytes from untreated rabbits, acute exposure to amiodarone in vitro reduced i.p. when patch pipettes contained 10 mM Na+ but had no effect on i.p. at 80 mM Na+. Amiodarone had no effect on the voltage dependence of the pump or the affinity of the pump for extracellular K+ either after chronic treatment or during acute exposure [4].Clinical trial: Continuous Versus Episodic Amiodarone Treatment for the Prevention of Permanent Atrial Fibrillation.

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  • Product application

 

Amiodarone hydrochloride can prevent some paroxysmal or ventricular tachycardia and ventricular fibrillation. It is also suitable for improving paroxysmal ventricular tachycardia when the drug effect is poor. It is also suitable for paroxysmal atrial flutter and atrial fibrillation.

 

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