|Product Name:||Mangostin||CAS No.:||6147-11-1|
|Molecular Formula:||C24H26O6||Molecular Weight:||410.46|
|Storage:||Cool And Dry|
99% Min Mangostin Powder,
Antiviral Mangostin Powder,
Mangosteen Extract CAS 6147-11-1
Plant Extract Powder Antibacterial, anti-inflammatory and antiviral Mangosteen Extract Mangostin CAS 6147-11-1
|COA||Please contact with Senwayer freely|
Mainly have anti-cancer, anti-oxidation, promote cell apoptosis, antibacterial, phytoestrogens and other effects.
1. Inhibition of cyclooxygenase
Cyclooxygenase participates in a variety of pathophysiological processes, and its high expression plays a significant role in promoting the occurrence and development of inflammation, pain, cardiovascular disease, senile dementia, and cancer. γ-mangostin can bind to the active sites of cyclooxygenase and can completely inhibit the activity of cyclooxygenase. α-Mangostin also inhibits the activity of cyclooxygenase, and the inhibitory concentration range is similar to that of γ-mangostin.
2, Phytoestrogen-like effect
The biological effects of phytoestrogens are mainly manifested in hormone-related diseases, such as breast cancer, cardiovascular disease, osteoporosis, menopausal syndrome, etc. Alpha-mangostin has a therapeutic effect on hormone-related diseases.
3, cell apoptosis effect
Α-mangostin's apoptosis-inducing effect makes it a new way for leukemia immunotherapy.
4, inhibit the effect of sphingomyelinase
Sphingomyelinase is a hydrolase of sphingomyelin, which is involved in the regulation of cell growth, differentiation, and apoptosis. It has a lot to do with the occurrence of intestinal tumors. α-can inhibit the activity of sphingomyelinase.
5. Antioxidant effect
The oxidation of low-density lipoprotein is very harmful to cardiovascular diseases and other chronic diseases
α-mangostin participates in various carcinogenic processes of protein kinase phosphorylation, including cancer cell proliferation, apoptosis, angiogenesis and metabolism, and has a certain inhibitory effect on tumor cells cultured in vivo and in vitro . γ-mangostin can inhibit the production of reactive oxygen species by mitochondrial catalase in U87MG and GBM8401 cells, thereby inhibiting tumor cell growth and promoting cancer cell apoptosis. Therefore, γ-mangostin can be developed as an anti-tumor with great potential Drug lead compounds. a-mangostin can also inhibit the proliferation of human chondrosarcoma cells
7. The effect of treating breast cancer
The higher the content of α- and γ-mangostin, the better the inhibitory effect of the same total extract on breast cancer cells. Mangostin can change the cell morphology of breast tumor cells and their dividing DNA fragments.
8, histamine H1 receptor antagonism
The inflammatory mediator histamine can induce allergic asthma and bronchospasm. Alpha-mangostin is a selective and competitive antagonist of histamine H1 receptor.
9, serotonin 2A receptor inhibition
Serotonin 2A (5-HT2A) receptors are related to cardiovascular diseases. 5-HT has a strong function of constricting blood vessels and promoting platelet aggregation. γ-mangostin can inhibit platelet aggregation.
10, antibacterial effect
Α-mangostin has strong antibacterial activity against Staphylococcus aureus which is sensitive to methicillin and toluicillin. α- and β-mangostin have a strong inhibitory effect on Mycobacterium tuberculosis.
11. Some researchers have found that α-mangostin has a significant effect on Canadian albinism; α- and γ-mangostin also have biological activities such as anti-inflammatory, chemical hypoxia resistance, analgesia, and hypoglycemic effects.
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