Home ProductsAPI Powder

Pure Oroxylin A API Powder CAS 480-11-5 Antidiabetic Herbal Drugs

Certification
China Wuhan Senwayer Century Chemical Co., Ltd. certification
China Wuhan Senwayer Century Chemical Co., Ltd. certification
Customer Reviews
everything was great. friendly and understanding representative and fast shipping(compared to other items on here). my shoulder feels much stronger and healthier after only one and a half weeks.

—— Terry Smith

Superb Excellence is all I can say about this Company and its products. I will continue to buy from this company. The service is excellent and the product matches the service. Thanks for the great product and service. I will be ordering from you really soon.

—— Brant huges

Love it I’ve been using it for a long time

—— Drew

I'm Online Chat Now

Pure Oroxylin A API Powder CAS 480-11-5 Antidiabetic Herbal Drugs

Pure Oroxylin A API Powder CAS 480-11-5 Antidiabetic Herbal Drugs
Pure Oroxylin A API Powder CAS 480-11-5 Antidiabetic Herbal Drugs

Large Image :  Pure Oroxylin A API Powder CAS 480-11-5 Antidiabetic Herbal Drugs

Product Details:
Place of Origin: China
Brand Name: Senwayer
Certification: GMP/ISO
Model Number: Oroxylin A
Payment & Shipping Terms:
Minimum Order Quantity: 100g
Packaging Details: 1KG per foil bag
Delivery Time: 5 working days
Payment Terms: T/T , bank transfer , Bitcoin , USDT
Supply Ability: 100KG per month

Pure Oroxylin A API Powder CAS 480-11-5 Antidiabetic Herbal Drugs

Description
Name: Oroxylin A CAS No.: 480-11-5
Molecular Formula: C16H12O5 Molecular Weight: 284.26
Melting Point: 195-197℃ Storage: 2-8°C
Appearance: Powder Purity: 98% Min
High Light:

C16H12O5 Oroxylin A API Powder

,

98% API Powder CAS 480-11-5

,

CAS 480-11-5 Antidiabetic Herbal Drugs

 Antidiabetic herbal medicine Oroxylin A powder CAS 480-11-5
 

 

What is Oroxylin A?

Oroxylin A, a methylated metabolite of baicalein, exhibits a stronger inhibitory effect than baicalein on the CYP1B1-mediated carcinogenic estradiol metabolite formation

 

Tumor necrosis factor alpha (TNFα) is a complicated cytokine which is involved in proliferation and differentiation of acute myelogenous leukemia (AML) cells through a poorly understood mechanism. Mechanistic studies indicate that TNFα induced binding of PI3K subunit p85α to N-terminal truncated nuclear receptor RXRα (tRXRα) proteins, and activated AKT. The activated PI3K/AKT pathway negatively regulated differentiation of AML cells through the upregulation of c-Myc. In addition, TNFα also induced activation of nuclear factor κB (NF-κB), a nuclear transcription factor which was shown to promote cell proliferation. The present study demonstrates that oroxylin A, a natural compound isolated from Scutellariae radix, sensitizes leukemia cells to TNFα and markedly enhances TNFα-induced growth inhibition and differentiation of AML cell including human leukemia cell lines and primary AML cells. Activation of PI3K/AKT pathway could be inhibited by oroxylin A through inhibiting expression of tRXRα in NB4 and HL-60-resistant cells. Furthermore, we found that oroxylin A inhibited the activation of NF-κB and the DNA binding activity by TNFα proved by EMSA in these two AML cell lines. Moreover, in vivo studies showed that treatment with oroxylin A in combination with TNFα decreased AML cell population and prolonged survival in NOD/SCID mice with xenografts of primary AML cells. Overall, our results indicate that oroxylin A is able to inhibit the negative effects of TNFα for AML therapy, suggesting that combination of oroxylin A and TNFα have the potential to delay growth or eliminate the abnormal leukemic cells, thus representing a promising strategy for AML treatment.

 

 

How to order from Senwayer
1. Send inquiry to let us know the product and quantity you need
2. Senwayer Team will provide with quotation
3. Make full payment then Senwayer Team will start to arrange shipment. (Bank transfer, Bitcoin, USDT)
4. Tracking number usually can be provided in 5 working days after payment received.
5. Parcel will arrive you safely.

 
 
Pure Oroxylin A API Powder CAS 480-11-5 Antidiabetic Herbal Drugs 0Pure Oroxylin A API Powder CAS 480-11-5 Antidiabetic Herbal Drugs 1

Contact Details
Wuhan Senwayer Century Chemical Co., Ltd.

Contact Person: kate

Tel: +8616607120890

Send your inquiry directly to us (0 / 3000)